Liver Detoxification Profile

Liver Detoxification Profile – Urine & Saliva

 

The process of detoxification is one of the chief roles of the liver. It works to convert lipid-soluble xenobiotics into water soluble substances that can be excreted from the body. It does this via a two-step process designated phase I and phase II. When the function of the liver is sub-optimal, toxins can build up and poison the body. The liver detoxification profile evaluates the ability of an individual to process caffeine, aspirin (salicylate) and paracetamol (acetaminophen) by assessing certain metabolites in salivary a

nd urinary specimens.

 

 

Analytes:

Phase I: Caffeine Clearance;

 

Phase 2: Acetaminophen glucuronide (glucuronidation), Salicyluric acid (glycination), Acetaminophen mercapturate (glutathionation), Acetaminophen sulphate (sulphation).

This test is unlike standard liver function tests which only provide a measure of hepatic damage (released hepatic enzyme levels). In contrast, the liver detoxification test is a true functional test as it evaluates the ability of an individual to process caffeine, aspirin (salicylate) and paracetamol (acetaminophen) by assessing certain metabolites in salivary and urinary specimens.

 

 

 

Specific measurements of the different phases of liver detoxification including phase I and phase II (glycination, glucuronidation, sulphation and glutathionation) are obtained, guiding the design of effective and specific therapeutic strategies which can optimise liver function.

 

 

 

Common Conditions:

  • Autism
  • Chronic fatigue
  • Food intolerances
  • Headaches
  • Multiple chemical sensitivities
  • Hormonal imbalances
  • Multiple drug therapy

 

Analytes:

Phase I: Caffeine Clearance; Phase 2: Acetaminophen glucuronide (glucuronidation), Salicyluric acid (glycination), Acetaminophen mercapturate (glutathionation), Acetaminophen sulphate (sulphation).

 

 

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